While their third-year counterparts are participating in the Clerkship Orientation, rising fourth-year students, seasoned with a full year of clinical experience, engage in an in-depth, seminar- and original-literature-based selective in advanced science. Students select from a palette of topics drawn from the frontiers of translational medicine and biomedical technology, making choices based upon their own individualized interests and emerging differentiated focus. Topics include Stem Cell Therapy, Models of Multigenic Disease, Vaccine Development, Neurobiology of Pain, Ion Channels and Disease, DNA Technology in Medicine, Anatomy for Surgeons, and the Microbiology of Bioterrorism.