Clinical Journal of the American Society of Nephrol. 2007 Jul;2 Suppl 1:S2-5.
Faulhaber JR, Nelson PJ.
Division of Infectious Diseases, New York University School of Medicine, New York, New York 10016, USA.
Significance:
Patients infected with viruses can develop many types of kidney diseases, in which cellular immune responses to the invading virus rather than the virus itself may play a dominant pathogenic role.
In this review, we focused on how adaptive immune responses to viruses can injure the kidney, raising the possibility that strategies to directly target these responses may carry therapeutic benefit.
Abstract:
Cellular immune systems play an important role in determining renal outcomes in virus-induced kidney diseases.
Highlighted briefly are five different locations along the development of adaptive immune responses to viral infection that may promote injury to the renal parenchyma and the loss of renal function. This may occur because adaptive immune cells directly target infected renal parenchymal cells or because the kidney becomes a bystander organ of adaptive immune cell-mediated injury.
Examples from recent studies are provided to illustrate how this may lead to clinically relevant renal disease.
PMID: 17699506
