Articles from the Department of
Medical Parasitology in 2005 - 7

• Wong KA and A Rodriguez. Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells. Journal of Immunology. In press.

• Frevert U, Usynin I, Baer K, and Klotz C. Penetrating Biological Barriers. Liver: Plasmodium Sporozoite Passage across the Sinusoidal Cell Layer. In: Molecular Mechanisms of Parasite Invasion. Soldati, D. & Burleigh, B. (eds). Landis Bioscience, Georgetown. In press.
  

• Yanow SK, Purcell LA, Pradel G, Sato A, Rodriguez A, Lee M, and Spithill TW. (2007). Potent antimalarial and transmission-blocking ac tivities of a novel DNA binding agent. Journal of Infectious Diseases. In Press.

• Sinnis P.  Giardia. In: Parasitology. A. Satoskar, G. Simon, P. Hotez and M. Tsuji (eds). Landes Bioscience, Austin Texas. In Press.

• JCR Hafalla, U Rai, D Bernal-Rubio, A Rodriguez, and F Zavala (2007). Efficient development of Plasmodium liver stage-specific memory CD8+ T cells during the course of blood stage malaria infection. Journal of Infectious Diseases. In Press.
  

• Usynin I, Klotz C, Frevert U. Malaria circumsporozoite protein inhibits the respiratory burst in Kupffer cells. Cell Microbiol. 2007 Nov 9(11);2610-2628.

• Coppi A., Tewari R., Bishop J.R., Bennett B.L., Lawrence R., Esko J., Billker O. and Sinnis P. Heparan sulfate proteoglycans provide a signal to Plasmodium sporozoites to stop migrating and productively invade cells. Cell Host & Microbe. 2007 Nov 2:316-327.

• Jin Y, C Kebaier, and J P Vanderberg.  Direct microscopic quantification of transmission dynamics of Plasmodium sporozoites from mosquitoes to mice. Infect. Immun. 2007 Nov 75(11): 5532-5539.
  

• Baer K, Klotz, Kappe SH, Schneider T, Frevert U. Resease of hepatic Plasmodium yoelii merozoites into the pulmonary microvasculature. PLoS Pathogens. 2007 Nov 3(11);e171.

• Frevert U, Spaeth G, Yee H. Exoerythrocyte development of Plasmodium gallinaceum in the White Leghorn chicken. Int. J. Parasitol. 2007 Oct 12 [ePub aheas of print].

• Vanderberg, JP.  Assessment of antibody protection against malaria sporozoites must be done by mosquito injection of sporozoites. Am. J. Path. 2007 Oct, 171: 1405.
  

• Sinnis P and Coppi A. A Long and Winding Road: The Plasmodium Sporozoite's Journey in the Mammalian Host. Parasitology International. 2007 Sept 56:171-178.

• Kelly BA, Neil SJ, McKnight A, Santos JM, Sinnis P, Jack ER, Middleton DA and Dobson CB.  Apolipoprotein E-derived anti-microbial peptide analogues with altered membrane affinity and increased potency and breadth of activity. FEBS Journal. 2007 Sept 274:4511-25.

• Turner N, Eichinger D. Entamoeba invadens: the requirement for galactose ligands during encystment. Exp. Parasitol. 2007 Aug 116(4);467-474.

• Sinnis P, Coppi A, Toida T, Toyoda H,  Kinoshita-Toyoda A, Xie J, Kemp MM and Linhardt RJ. Mosquito heparan sulfate and its potential role in malaria infection and transmission. J. Biol. Chem. 2007 Aug 282: 25376-84.

• Carapau D, Kruhofer M, Chatalbash A, Orengo JM, Mota MM and A Rodriguez. Transcriptome profile of dendritic cells during malaria: cAMP regulation of IL-6. Cell Microbio. 2007 July 9(7):1738-52.

• Ocana-Morgner C, Wong KA, Lega F, Dotor J, BOrras-Cuesta F, Rodriguez A. Role of TGF-b and PGE2 in T-cell responses during P. yoelii infection. European J Immunol. 2007 June 37(6);1562-74.

• Imwong M, Snounou G, Pukrittayakamee S, Tanomsing N, Kim JR, Nandy A, Guthmann JP, Nosten F, Carlton J, Looareesuwan S, Nair S, Sundimack D, Day NP, Anderson TJ, White NJ. Relapses of Plasmodium vivax infection usually result from activation of heterologous hypnozoites.J Infect Dis. 2007 Apr 1;195(7):927-33.

• Bhandari R, Janos DP and Sinnis P. Furuncular myiasis in a returning traveler caused by Dermatobia hominis. Am J. Trop. Med. Hyg. 2007 Mar;76:598-599.

• Barry AE, Leliwa-Sytek A, Tavul L, Imrie H, Migot-Nabias F, McVean GAV, Day KP. Population genomics of the immune evasion (var) genes of Plasmodium falciparum. PLoS Pathogens 2007 Mar 13;3(3):e34

• Carapau D, Kruhofer M, Chatalbash A, Orengo JM, Mota MM, Rodriguez A. Transcriptome profile of dendritic cells during malaria: cAMP regulation of IL-6. Cell. Micro. 2007 Feb 22;[ePub ahead of print].

• Yamauchi LM, Coppi A, Snounou G and Sinnis P. Plasmodium sporozoites trickle out of the injection site. Cell. Microbio. 2007 9(5):1215-1222.

• Teixeira, M.C.A., Oliveira, G.G.S., Silvany, M.A., Alcantara-Nueves, N.M., Soares, M.B.P., Ribeiro-dos-Santos, R., Jeronimo, S.M.B., Costa, C.H., dos-Santos, W.L.C., Eichinger, D., Pontes-de-Carvalho, L. 2006. A strategy for identifying serodiagnostically relevant antigens of Leishmania or other pathogens in genetic libraries. Biologicals. 2007 35(1):51-54.

• Takeshi Ono, Takushi Tadakuma and Ana Rodriguez. Plasmodium yoelii constitutively expressing GFP throughout the life cycle. Experimental Parasitology. 2007 Mar:115(3);310-13, e-pub Oct 2006.

• Imrie H, Fowkes FJI, Michon P, Tavul L, Reeder J, Day KP. Low prevalence of an acute phase response in asymptomatic children from a malaria endemic area of Papua New Guinea. Am. J Trop. Med. Hyg. 2007 Feb:76(2);280-4.

• Baer K, Roosevelt M, Van Rooijen N, Clarkson Jr AB and Frevert U. Kupffer cells are obligatory for Plasmodium sporozoite infection of the liver. Cell. Microbiol. 2007 Feb:9(12);397-412.

• Jane M. Carlton, Robert P. Hirt, Joana C. Silva, Arthur L. Delcher, Michael Schatz, et al. Draft genome sequence of the sexually-transmitted pathogen Trichomonas vaginalis. Science. 2007 Jan 12:315(5809);207-12.

• Ehrenkaufer GM, Haque R, Hackney JA, Eichinger D, Singh U. Identification of developmentally regulated genes in Entamoeba histolytica: insights into mechanisms of stage conversion in a protozoan parasite. Cell Microbiol. 2007 Jan 22 [ePub ahead of print].

• Volkman SK, Lozovsky E, Barry AE, Bedford T, Bethke L, Myrick A, Day KP, Hartl DL, Wirth DF, Sawyer SA. Genomic heterogeneity in the density of noncoding single-nucleotide and microsatellite polymorphisms in Plasmodium falciparum. Gene 2007 Jan 31:387(1-2);1-6).

• Jane M Carlton. Towards a malaria haplotype map. Nature Genetics. 2007 Jan:39(1);5-6.

• Cosgrove, C.L., Day, K.P., & Sheldon, B.C. Co-amplification of Leucocytozoon by PCR diagnostic tests for avian malaria: a cautionary note. Parasitology. 2006 Dec:92(6);1362-1365.

• Cosgrove, C. L., Knowles, S. C. L., Day, K. P. & Sheldon, B. C. No evidence for malaria infection during the nestling phase in a passerine bird. Parasitology. 2006 Dec:92(6):1302-1304.

• Kebaier, C. and J. P. Vanderberg. Re-ingestion of Plasmodium berghei sporozoites after delivery into the host by mosquitoes. Am. J. Trop. Med. Hyg. 2006 Dec:75(6);1200-4.

• Kumar KA, Sano G, Boscardin S, Nussenzweig RS, Nussenzweig MC, Zavala F, Nussenzweig V. The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites. Nature. 2006 Dec 14:444(7121);937-40.

• Calvo-Calle, J.M., Oliveira, G.A., Othoro-Watta,C., Severow, J., Parra-Lopez, C., and Nardin, E.H. A linear peptide containing minimal T and B cell epitopes of Plasmodium falciparum circumsporozoite protein elicits protection against transgenic sporozoite challenge. Infect. Immun. 2006 Dec:74(12);6929-39.

• Tarun AS, Baer K, Dumpit RF, Gray S, Lejarcegui N, Frevert U, Kappe SHI. Quantitative isolation and in vivo imaging of malaria parasite liver stages. Int. J. Parasitol. 2006 Oct:36(12);1283-1293.

• Frevert U, Usynin I, Baer K and Klotz C. Nomadic or sessile: can Kupffer cells function as portals for malaria sporozoites to the liver? Cell Microbiol. 2006 Oct:8(10);1537-1546.

• Eisen JA, Coyne RS, Wu M, Wu D, Thiagarajan M, Wortman JR, Badger JH, Ren Q, Amedeo P, Jones KM, Tallon LJ, Delcher AL, Salzberg SL, Silva JC, Haas BJ, Majoros WH, Farzad M, Carlton JM, et al. Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote. PLoS Biol. 2006 Sep;4(9):e286.

• Barry, A. E., Leliwa, A., Man, K., Kasper, J.M., Hartl, D.L., Day, K.P. Variable SNP density in aspartyl protease genes of the malaria parasite Plasmodium falciparum. Gene. 2006 Jul 19:376(2);163-73.

• Imrie, H., Fowkes, F. J.I., Michon, P., Tavul, L., Hume, J.C.C., Piper, K.P., Reeder, J.C., Day, K.D. Haptoglobin levels are associated with haptoglobin genotype and alpha+ -thalassemia in a malaria endemic area. Am. J. Trop. Med. Hyg. 2006 June;74(6):965-71.

• J.C. Hafalla, U. Rai U, A. Morrot, D. Bernal-Rubio, F. Zavala and A. Rodriguez. Priming of CD8+ T cell responses following immunization with heat-killed Plasmodium sporozoites. European Journal of Immunology. 2006 May;36(5): 1179-86.

• Coppi, A., Cabinian, M., Mirelman, D. and Sinnis, P. Antimalarial Activity of Allicin, a Biologically Active Compound From Garlic Cloves. Antimicrobial Agents and Chemotherapy. 2006 May;50(5):1731-1737.

• Frevert U. Response to Heussler and Doering: In vivo imaging enters parasitology. Trends Parasitol. 2006 April;22: 195-196.

• Parra-Lopez, C., Calvo-Calle, J.M., Cameron, TO, Vargas LE, Salazar LM, Patarroyo ME, Nardin, E and Stern, LJ. Major histocompatibility complex and T cell interctions of a universal T cell epitope from Plasmodium falciparum circumsporozoite protein. J.Biol. Chem. 2006. 281:14907-17.

• Silvia B. Boscardin, Julius C.R. Hafalla, Alice O. Kamphorst, Revati F. Masilamani, Henry A. Zebroski, Alexandre Morrot, Fidel Zavala, Ralph M. Steinman, Ruth S. Nussenzweig and Michel C. Nussenzweig. Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses. J. Exp Med. 2006 Mar;203(3):599-606.

• Engelmann S, Sinnis P, Matuschewski K. Transgenic Plasmodium berghei sporozoites expressing beta-galactosidase for quantification of sporozoite transmission. Mol Biochem Parasitol. 2006 Mar;146(1):30-7.

• Fowkes, F, Imrie, H, Migot-Nabias, F, Michon, P, Justice, A, Deloron, P, Luty, A, and Day, KP. Association of haptoglobin levels with age, parasite density, and haptoglobin genotype in a malaria-endemic area of Gabon. American Journal of Tropical Medicine and Hygiene. 2006 Jan;74(1):26-30.

• Korochkina S, Barreau C, Pradel G, Jeffery E, Li J, Natarajan R, Shabanowitz J, Hunt D, Frevert U, Vernick KD. A mosquito-specific protein family includes candidate receptors for malaria sporozoite invasion of salivary glands. Cell Microbiol. 2006 Jan;8: 163-75.

• Molina-Portela, MP, Lugli, E., Recio-Pinto, E. and Raper. J. Trypanosome lyitc factor, a subclass of high-density lipoprotein, forms cation-selective pores in membranes. Mol. Biochem. Parasitol. 2005 Dec;144(2):218-26.

• Calvo-Calle, J.M., Oliveira, G.A. and Nardin, E.H. Human CD4+ T cells induced by synthetic peptide malaria vaccine are comparable to cells elicited by attenuated P. falciparum sporozoites. J. Immunol. 2005 Dec 1;175(11):7575-85.

• Langermans, J.A.M., Schmidt, A., Vervenne, R.A.W., Birkett, A.J., Calvo-Calle, J.M., Hensmann, M., Thornton, G.B., Dubovsky, F., Weiler, H., Nardin, E. and Thomas, A.W. Effect of adjuvant on reactogenicity and long-term immunogenicity of the malaria vaccine Icc-1132 in Macaques. Vaccine. 2005 Sept 3-;23(41):4935-43.

• Medica DL, Sinnis P. Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected anopheline mosquitoes. Infect Immun. 2005 Jul;73(7):4363-9.

• Byers, J. and Eichinger, D. Entamoeba invadens: restriction of ploidy by colonic short chain fatty acids. Exp Parasitol. 2005 Jul;110(3):203-6.

• Frevert U, Engelmann S, Zougbede S, Stange J, Ng B, Matuschewski K, Liebes L, Yee H., Intravital observation of Plasmodium berghei sporozoite infection of the liver. PLoS Biol. 2005 Jun;3(6):e192.

• Oliveira GA, Wetzel K, Calvo-Calle JM, Nussenzweig R, Schmidt A, Birkett A, Dubovsky F, Tierney E, Gleiter CH, Boehmer G, Luty AJ, Ramharter M, Thornton GB, Kremsner PG, Nardin EH. Safety and enhanced immunogenicity of a hepatitis B core particle Plasmodium falciparum malaria vaccine formulated in adjuvant Montanide ISA 720 in a phase I trial. Infect Immun. 2005 Jun;73(6):3587-97.

• Leiriao P, Mota MM, Rodriguez A. Apoptotic Plasmodium-infected hepatocytes provide antigens to liver dendritic cells. J Infect Dis. 2005 May;191(10):1576-81.

• Frevert U, Nardin E. Arrest in the liver--a genetically defined malaria vaccine? N Engl J Med. 2005 Apr;352(15):1600-2.

• Shivji M, Burger S, Moncada CA, Clarkson AB Jr, Merali S. Effect of nicotine on lung S-adenosylmethionine and development of Pneumocystis pneumonia. J Biol Chem. 2005 Apr;280(15):15219-28.

• Leiriao P, Albuquerque SS, Corso S, van Gemert GJ, Sauerwein RW, Rodriguez A., Giordano S, Mota MM. HGF/MET signalling protects Plasmodium-infected host cells from apoptosis. Cell Microbiol. 2005 Apr;7(4):603-9.

• Byers, J., Faigle, W., Eichinger D. Colonic short-chain fatty acids inhibit encystation of Entamoeba invadens. Cell Microbiol. 2005 Feb;7(2):269-79.

• Mueller AK, Camargo N, Kaiser K, Andorfer C, Frevert U, Matuschewski K, Kappe SH. Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface. Proc Natl Acad Sci U S A. 2005 Feb;102(8):3022-7.

• Tao D, Barba-Spaeth G, Rai U. Nussenzweig V, Rice C and Nussenzweig R.S. Yellow Fever 17D as a vaccine vector for microbial CTL epitopes: Protection in a rodent malaria model. J Exp. Med. 2005 Jan;201(2):201-209.

• Coppi, A., Pinzon-Ortiz, C., Hutter, C. and Sinnis, P. The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion. J. Exp. Med. 2005 Jan;201(1):27-33.