Investigations of neuronal ion channels led to the discovery of a new class of voltage-dependent calcium channel named the P-type for the Purkinje cell where it was first detected. We now study the structure and function of this channel using various biochemical methods and the lipid-bilayer technique.

Using cell transplant methods, we recently found that adult cells implanted into the brain show longterm viability and maintain function if they are adhered to micro-carriers before implantation. Our results suggest this method is far superior to fetal transplants, and we are actively pursuing this exciting area for treatment of neurodegenerative disease, including Parkinson disease.