The Faculty

Below is a list of Program Faculty and their Research Interests.
Click on their Names or Research Interests to learn more about them.

    In the Department of Biochemistry
Dafna Bar-Sagi, Ph.D. Signal Transduction In Growth Control And Cancer
James Borowiec, Ph.D. Regulation of Cellular Checkpoints and DNA Repair in Higher Eukaryotes
Tony Huang, Ph.D. Regulation of Ubiquitination and Deubiquitination in DNA Repair and Cancer Susceptibility Pathways
Hannah L. Klein, Ph.D. Genes Involved in Protection Against Genomic Instability From DNA Damage;
Rregulation of the Response to DNA Damage;
Role of Cohesins and Centromeres in Recombination and Repair
Xiangpeng Kong, Ph.D. Immunology & Pathogenesis UPEC invasion of urothelium - host-pathogen interactions in urinary tract infection (UTI);
Structure-based HIV vaccine design
Evgeny A. Nudler, Ph.D. RNA Polymerase as a Molecular Machine: How It Moves, Responds to Elongation Factors and Terminates;
The Role of theHheat Shock Response in Tumorigenesis;
New Virulence Factors andAantimicrobial Targets in Bacillus anthraces and Other Pathogens
Danny Reinberg, Ph.D. Regulation of Gene Expression in Eukaryotic Cells
Edward B. Ziff, Ph.D. Regulation of AMPA-type Glutamate Receptors at Synapses;
Mechanisms of Synaptic Plasticity; Synapse Architecture; the Biochemical Basis of Behavior Formation;
Trafficking of AMPA-type Glutamate Receptors at Synapses- Actin and the Biogenesis of Dendritic Spines;
The Pharmacology of Neuroprotection;
Neurodegenerative Diseases, Including Alzheimer's Disease and ALS;

      In the Department of Cell Biology
Milton Adesnik, Ph.D. Control of Exocytotic and Endocytic Protein Transport
Moses Chao, Ph.D. Signal Transduction Mechanisms of Receptor Tyrosine Kinases: EGF/Neuregulin, NGF, VEGF and Ephrin Famalies;
Trophic Factors; Synapse Formation; Synaptic Vesicle Recycling and Post-synaptic Ion Channel Function;
Receptor Endocytosis; Endosomal Protein Trafficking and Signaling; ER-ERGIC-Golgi Secretory Mechanisms
Pamela Cowin, Ph.D. Cell Adhesion and Wnt Signaling
Edward A. Fisher, Ph.D., M.P.H., M.D. The cell biology of hepatic lipid and lipoprotein metabolism;
The molecular biology of vascular diseases
Alan B. Frey, Ph.D. T Cell Immune Responses;
Regulation of Signal Transduction in Tumor-Infiltrating CD8+ T Cells
Gert Kreibich, Ph.D. Synthesis, Assembly and Sorting of Membrane Proteins
Paolo Mignatti, M.D. Growth Factors and Proteinases in Tumor Invasion and Angiogenesis
John S. Munger, M.D. Regulation of Pulmonary Inflammation and Fibrosis
Ralph Nixon, Ph.D., M.D. Molecular Mechanisms of Alzheimer's Disease
Mark Philips, M.D. How Localization Affects the Signaling Output of Ras and Rho Proteins;
Ras Pathway in Human cancers; Characterization of Icmt, the Enzyme that Methylates Ras, as a Potential Target for Anti-cancer Drug Discovery;
Ppost-translational Processing and Trafficking of Ras and Related CAAX Proteins;
Ras and Rap1 Signaling Pathways in Lymphocytes
Daniel B. Rifkin, Ph.D. Mechanisms of Cell Invasion
David Ron, M.D. Stress-induced Gene Expression in Unfolded Protein Responses:
Cellular Adaptation to Misfolded Protein Stress in Organelles;
Discover Compounds That Modulate Signaling in the Unfolded Protein Response
HyungDon Ryoo, Ph.D. Regulation of Stress Response and Apoptosis in Drosophila;
Regulation of Apoptosis During Drosophila Development
David D. Sabatini, M.D., Ph.D. Protein Sorting in Eukaryotic Cells
James L. Salzer, M.D., Ph.D. Elucidation of the Intracellular Signaling Pathways of Myelination and Demyelination;
Ion Channel Targeting and the Molecular Organization of Axons in Myelinated Nerves
Tung-Tien Sun, Ph.D. Structure, Function and Disease Implications of Urothelial Membrane Plaques
E. Lynette Wilson, Ph.D. Biology of Stem Cells

     In the Department of Chemistry
Paramjit Arora, Ph.D. Design and Synthesis of Small Molecule Ligands for Sequence-specific Recognition of DNA;
Small Molecule Inhibitors of Protein-protein Interactions
Kent Kirshenbaum, Ph.D. Bioorganic Chemistry, Biomimetic Chemistry, Protein Conformation and Dynamics, Macromolecular Design

     In the Department of Microbiology
Joel Belasco, Ph.D. Post-Transcriptional Gene Regulation
Robert Schneider, Ph.D. Altered Regulation of Gene Expression in Carcinognesis and Cell Stress
Naoko Tanese, Ph.D. Chromatin and Regulation of Eukaryotic Gene Transcription ;
Role of Huntington's Disease Protein in Post-transcriptional Pathways

         In the Department of Pathology
Michael Dustin, Ph.D. Imunological Synapse Formation;
Coordination of the Immune Response by Chemokines:
Biophysics of Adhesion Molecule Interactions:
Regulation of LFA-1 Activation:
In vivo Imaging of T Cell migration and Activation
Brian D. Dynlacht, Ph.D. Controls That Govern Mammalian Cell Cycle Regulation;
Transcription and Epigenetic Regulators of Cell Growth and Differentiation
Michelle Krogsgaard, Ph.D. Cellular and Molecular Mechanisms of Immunoregulatory Functions of Dendritic Cells
Michele Pagano, M.D. Regulation of the Mammalian Cell Cycle
and its Deregulation in Cancer
Angel Pellicer, M.D., Ph.D. The Physiologic Function of the Ras Genes and Their Role in Malignant Development
Susan Smith, Ph.D. Molecular Basis of Telomere Function
E. Sergio Trombetta, Ph.D. Novel Imaging and Biophysical Methods to Understand the Structure;
Function of T-Cell Recognition and Mechnisms of T-Cell Responses To Self

   In the Department of Pharmacology
Susan K. Logan, Ph.D. Cross Talk Between Steroid Hormone Receptors and Cytokine and Growth Factor Stimulated Signal Transduction Pathways;
Androgen Receptor Regulation of Gene Expression;
Androgen Regulation of Male Development;
Regulation of Androgen Receptor Signaling Through Receptor Modification and Interaction With Cofactors;
The Role of the Androgen Receptor in Prostate and Breast Cancer
Herbert H. Samuels, M.D. Regulation of Gene Expression by Nuclear Hormone Receptors