Carotid Revascularization Endarterectomy vs. Stent Trial (CREST)
Principal Investigator: Neal Cayne, MD
Co-investigators:
Mark Adelman, MD
Glenn Jacobowitz, MD
Thomas Riles, MD
Thomas Maldonado, MD
Patrick Lamparello, MD
Contact: Jacqueline Bott, RN, (212) 263-2268 jacqueline. bott@nyumc.org
The NYU CREST trial contrasts the relative efficacy of Carotid Artery Stenting (CAS) versus Carotid Endarterectomy (CEA) in preventing stroke, myocardial infarction, and death during a 30 day peri-procedural period, and stroke ipsilateral to the study artery over the follow-up period in patients with symptomatic and asymptomatic extracranial carotid stenosis.
This trial is sponsored by the National Institutes of Health (NIH) and the University of Medicine and Dentistry of New Jersey (UMDNJ).
Asymptomatic Carotid Stenosis, Stenting vs. Endarterectomy Trial (ACT 1)
Principal Investigator: Neal Cayne, MD
Co-investigators:
Glenn Jacobowitz, MD
Mark Adelman, MD
Thomas Riles, MD
Patrick Lamparello, MD
Thomas Maldonado, MD
Contact: Jacqueline Bott, RN, (212) 263-2268, jacqueline. bott@nyumc.org
This multi-center randomized trial seeks to demonstrate that carotid artery stenting (CAS) using the Emboshield Cerebral Protection System with the Xact RX Carotid Stent System is equally effective to carotid endarterectomy (CEA) in treating asymptomatic extracranial carotid stenotic disease.
This trial evaluates stroke, myocardial infarction and death during a 30-day post-procedural period and ipsilateral stroke between 31 and 365 days post-procedure.
This trial is sponsored by Abbott Vascular Devices.
The Embolic Protection with Reverse Flow (EMPiRE) Study of the GORE Neuro Protection System in Carotid Stenting of Subjects at High Risk for Carotid Endarterectomy
Principal Investigator: Thomas Maldonado, MD
Co-investigator: Neal Cayne, MD
Contact: Jacqueline Bott, RN, (212) 263-2268 jacqueline. bott@nyumc.org
This multi-center trial assesses the safety and effectiveness of the GORE Neuro Protection System (NPS) in providing embolic protection during carotid artery angioplasty and stenting (CAS) procedures.
In this study, the GORE NPS is used to provide embolic protection during CAS procedures using FDA-approved carotid stents.
This study compares the results of CAS with GORE NPS embolic protection in high-risk surgical subjects to a weighted historical control of embolic protection CAS studies.
This trial is sponsored by W.L. Gore & Associates, Inc.
Carotid artery plaque characterization using helical CT: The effect of plaque morphology on microemboli and neuropsychiatric morbidity following carotid endarterectomy and carotid artery stent procedures
Principal Investigator: Thomas Maldonado, MD
Contact: Jacqueline Bott, RN, (212) 263-2268 jacqueline. bott@nyumc.org
This trial studies the occurrence of neurological changes based on cognitive testing done before and after carotid artery surgery (CAS), including carotid artery endarterectomy (CAE).
Researchers examine each subject’s pre-operative computed tomography (CT) scan to see if it can predict any of these neurological changes and also identify the type of material that is blocking the carotid artery.
Testing is performed before the surgery, on the first day after surgery, and one month following surgery.
This trial is sponsored by Medical Metrx Solutions, Inc.
